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Characteristics
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MSC Group (n = 9)
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Control Group (n = 9)
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P
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|---|
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Median age, years (range)
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4 (1-10)
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5 (3-9)
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0.438
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Gender, male / female
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3 / 6
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5 / 4
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0.637
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Type of AA
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SAA, n (%)
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2 (22%)
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4 (44%)
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0.620
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vSAA, n (%)
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7 (78%)
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5 (56%)
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Median duration from diagnosis to ATG treatment, days (range)
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26 (9-159)
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39 (26-179)
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0.281
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Median WBC, ×109/L (range)
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1.84 (0.57-4.79)
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2.60 (0.65-5.23)
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0.699
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Median HGB, g/L (range)
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76 (47-117)
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65 (47-105)
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0.475
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Median PLT,×109/L (range)
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10 (1-18)
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8 (4-19)
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0.500
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Median ANC,×109/L (range)
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0.07 (0-0.36)
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0.13 (0.01-0.41)
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0.229
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Median ARC,×109/L (range)
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5.4 (2.6-32.8)
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4.5 (2.2-17.0)
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0.587
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Median percentage of CD3 + CD4+ T-cell lymphocytes, % (range)
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39.6 (35.7-42.9)
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43.2 (28.4-73.0)
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0.401
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Median percentage of CD3 + CD8+ T-cell lymphocytes, % (range)
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25.6 (14.1-35.1)
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25.8 (9.4-35.2)
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0.885
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Median percentage of Tregs, % (range)a
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7.0 (3.5-9.4)
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6.7 (2.2-16.8)
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0.763
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Median percentage of mature lymphocytes in BM, % (range)
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94.1 (44.5-98.5)
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87.9 (36.2-97.7)
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0.306
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- Abbreviations: AA Aplastic anemia, SAA Severe aplastic anemia, vSAA Very severe aplastic anemia, ATG Antithymocyte globulin, WBC White blood cell, HGB Hemoglobin, PLT Platelet, ANC Absolute neutrophil count, ARC Absolute reticulocyte count, Tregs CD4 + CD25 + CD127dim regulatory T cells, BM Bone marrow
- aThe normal range of Tregs is 5-10%
