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Table 4 Analysis of predictors for mortality in 174 hospitalized children with ESKAPEEc BSI

From: Epidemiology, risk factors and outcomes of bloodstream infection caused by ESKAPEEc pathogens among hospitalized children

Variable non-survivors n = 25 survivors n = 149 Univariate analysis Logistic Regression Analysis#
P Value P Value Odds Ratio (95% CI)
Male, No. (%) 10 (40.0) 61 (40.9) 0.930   
Age (m), Median (IQR) 3.6 (0.8–33.5) 3.0 (0.6–36.0) 0.909   
Presence of any underlying disease, No. (%) 20 (80.0) 91 (61.1) 0.068   
Premature and/or low birth weight, No. (%) 8 (32.0) 47 (31.5) 0.964   
Tumor diseases, No. (%) 4 (16.0) 25 (16.8) 1.000   
Aplastic anemia, No. (%) 1 (4.0) 2 (1.3) 0.909   
Congenital heart disease, No. (%) 1 (4.0) 10 (6.7) 0.943   
Lung disease, No. (%) 1 (4.0) 11 (7.4) 0.848   
Digestive disease, No. (%) 5 (20.0) 10 (6.7) 0.071   
Kidney diseas, No. (%) 1 (4.0) 3 (2.0) 1.000   
Other disease, No. (%) 4 (16.0) 7 (4.7) 0.088   
Nosocomial infection, No. (%) 5 (20.0) 51 (34.2) 0.156   
Previous surgery and/ or trauma (within 3 months), No. (%) 8 (32.0) 16 (10.7) 0.011 0.006 7.006 (1.761–27.876)
Previous hospitalization (within 1 month), No. (%) 5 (20.0) 28 (18.8) 1.000   
Previous antibiotic use (within 1 month), No. (%) 2 (8.0) 45 (30.2) 0.021 0.034 0.132 (0.020–0.860)
Likely source of infections
 Lung infection, No. (%) 5 (20.0) 26 (17.4) 0.979   
 Abdominal infection, No. (%) 6 (24.0) 21 (14.1) 0.333   
 Urinary infection, No. (%) 1 (4.0) 25 (16.8) 0.175   
 Intracranial infection, No. (%) 0 2 (1.3) 1.000   
 Skin or soft tissue infection, No. (%) 0 20 (13.4) 0.082   
 Primary BSI, No. (%) 12 (48.0) 63 (42.3) 0.593   
Laboratory findings
 White blood cell count (*10^9),Median (IQR) 6.9 (3.5–11.3) 9.7 (5.3–13.9) 0.095   
 Neutrophil percentage, Median (IQR) 41.0 (9.5–63.1) 58.0 (34.8–72.7) 0.019 0.072 0.979 (0.957–1.002)
 Hemoglobin (g/L), Median (IQR) 97.0 (72.5–138.0) 110 (95–147.5) 0.026 0.218 0.990 (0.973–1.006)
 Platelet count ((*10^9), Median (IQR) 134 (41–227) 216 (117.5–352.0) 0.002 0.037 0.996 (0.991–1.000)
 C-reactive protein (mg/dL), Median (IQR) 29 (6–132) 13 (3–80.5) 0.068   
 Elevated ALT, No. (%) 12 (48.0) 44 (29.5) 0.067   
 Elevated AST, No. (%) 15 (60.0) 75 (50.3) 0.371   
 MODS, No. (%) 7 (28.0) 8 (5.4) 0.001 0.752 1.288 (0.268–6.197)
 Septic shock, No. (%) 4 (16.0) 9 (6.0) 0.180   
 Blood products transfusion, No. (%) 23 (92.0) 103 (69.1) 0.018 0.581 0.597 (0.096–3.720)
 Indwelling catheter, No. (%) 19 (76.0) 96 (64.4) 0.258   
 Indwelling gastric tube, N(%) 14 (56.0) 61 (40.9) 0.159   
 Central venous catheter, N(%) 10 (40.0) 66 (44.3) 0.689   
 Urinary catheter, N(%) 2 (8.0) 5 (3.4) 0.587   
 Mechanical ventilation, N(%) 13 (52.0) 31 (20.8) 0.001 0.004 7.997 (1.906–33.546)
 PICU admission, No. (%) 9 (36.0) 22 (14.8) 0.022 0.137 3.065 (0.701–13.408)
 Inappropriate empirical treatment, No. (%) 9 (40.9)* 37 (25.3)* 0.127   
  1. The interpretation for the abbreviations were listed in Table 2 legend
  2. Elevated ALT means ALT was > 40 U/L. Elevated AST means AST was > 45 U/L.
  3. # P value of Hosmer-Lemeshow goodness-of-fit test was 0.098
  4. *Percentage derived from the results of non-survivors group (n=2) and survivors group (n=146) with resistance data 
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