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  1. Scabies is a neglected tropical disease caused by the mite Sarcoptes scabiei that burrows under the skin. It is a major health problem in tropical areas, largely affecting children. Scabies is common and highly c...

    Authors: Alireza Sanei-Dehkordi, Moussa Soleimani-Ahmadi, Mehdi Zare and Seyed Aghil Jaberhashemi

    Citation: BMC Pediatrics 2021 21:249

    Content type: Research

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  2. Rickets is not an unusual diagnosis for pediatricians even currently in developed countries. Children typically present with leg bowing, enlargement of wrists, rachitic rosary (swelling of costochondral juncti...

    Authors: Patricia Diaz Escagedo, Melissa Fiscaletti, Patricia Olivier, Chloé Hudon, Valancy Miranda, Marie-Claude Miron, Philippe M. Campeau and Nathalie Alos

    Citation: BMC Pediatrics 2021 21:248

    Content type: Case report

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  3. The idea of the ‘30 million word gap’ suggests families from more socioeconomically advantaged backgrounds engage in more verbal interactions with their child than disadvantaged families. Initial findings from...

    Authors: Mary E. Brushe, John Lynch, Sheena Reilly, Edward Melhuish, Murthy N. Mittinty and Sally A. Brinkman

    Citation: BMC Pediatrics 2021 21:247

    Content type: Research article

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  4. Childhood obesity represents a global public health crisis: the number of obese children and adolescents (aged 5–19 years) worldwide has risen tenfold in the past four decades. The vast majority of overweight ...

    Authors: C. Homs, P. Berruezo, G. Según, L. Estrada, J. de Bont, J. Riera-Romaní, E. Carrillo-Álvarez, H. Schröder, R. Milà and S. F. Gómez

    Citation: BMC Pediatrics 2021 21:246

    Content type: Study protocol

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  5. Overweight can be a precursor of poor motor execution, negatively impacting the overall development of school-aged children on various levels. This study determined the long-term influences of overweight on pe...

    Authors: Elna de Waal and Anita Elizabeth Pienaar

    Citation: BMC Pediatrics 2021 21:245

    Content type: Research article

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  6. To evaluate the impact of compliance on the therapeutic effects of Desmopressin, as well as the importance of establishing the voiding school for low-compliance children in primary monosymptomatic enuresis tre...

    Authors: Zoran Radojicic, Sasa Milivojevic, Irena Koricanac, Jelena Milin Lazovic, Darko Laketic, Ognjen Radojicic and Natasa Milic

    Citation: BMC Pediatrics 2021 21:244

    Content type: Research article

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  7. There are few non-invasive monitoring methods that can reliably predict fluid responsiveness (FR) in children. Here, we interrogate the value of doppler ultrasound evaluation of passive leg raising (PLR)-induc...

    Authors: Deqiang Luo, Wei Dai, Lei Lei and Xueying Cai

    Citation: BMC Pediatrics 2021 21:243

    Content type: Research article

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  8. Spinal arteriovenous malformations in children are extremely rare and pose great risk for intraoperative hemorrhage. Congenital syphilis sometimes presents with vascular symptoms, however, there is little publ...

    Authors: Mia J. Bertoli, Kruti Parikh, David Klyde, Catherine A. Mazzola and Shridevi Pandya Shah

    Citation: BMC Pediatrics 2021 21:242

    Content type: Case report

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  9. To establish reference intervals for hemoglobin and mean corpuscular volume (MCV) in an ethnically diverse community sample of Canadian children 36 months and younger.

    Authors: Jemila S. Hamid, Eshetu G. Atenafu, Cornelia M. Borkhoff, Catherine S. Birken, Jonathon L. Maguire, Mary Kathryn Bohn, Khosrow Adeli, Mohamed Abdelhaleem and Patricia C. Parkin

    Citation: BMC Pediatrics 2021 21:241

    Content type: Research article

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  10. The number of children diagnosed with developmental disabilities (DDs) or other chronic difficulties has risen. However, each professional’s awareness of children with developmental, emotional and behavioural ...

    Authors: Ayako Ide-Okochi, Hiromi Funayama and Yoshinobu Asada

    Citation: BMC Pediatrics 2021 21:240

    Content type: Research article

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  11. Suboptimal child nutrition remains the main factor underlying child undernutrition in Democratic Republic of Congo (DRC). This study aimed to assess the prevalence of minimum acceptable diet and associated fac...

    Authors: Richard Mbusa Kambale, Gaylord Amani Ngaboyeka, Joe Bwija Kasengi, Sarah Niyitegeka, Boss Rutakaza Cinkenye, Armand Baruti, Kizito Chentwali Mutuga and Dimitri Van der Linden

    Citation: BMC Pediatrics 2021 21:239

    Content type: Research article

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  12. Fever is a common symptom in children presenting to the Emergency Department (ED). We aimed to describe the epidemiology of systemic viral infections and their predictive values for excluding serious bacterial...

    Authors: Christina A. Rostad, Neena Kanwar, Jumi Yi, Claudia R. Morris, Jennifer Dien Bard, Amy Leber, James Dunn, Kimberle C. Chapin, Anne J. Blaschke, Judy A. Daly, Leslie A. Hueschen, Matthew Jones, Elizabeth Ott, Jeffrey Bastar, Kevin M. Bourzac and Rangaraj Selvarangan

    Citation: BMC Pediatrics 2021 21:238

    Content type: Research article

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  13. Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is a common form of neonatal jaundice. Histopathological examination of the liver in patients with NICCD typically shows fatty liver, steat...

    Authors: Ryosuke Miyamoto, Jun Sada, Koki Ota, Kenitiro Kaneko, Hironori Kusano, Yoshiteru Azuma and Akihisa Okumura

    Citation: BMC Pediatrics 2021 21:237

    Content type: Case report

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  14. Spinal Muscular Atrophy (SMA), a leading genetic cause of death in infants, is an autosomal recessive neuromuscular disease characterized by progressive muscle weakness and atrophy. While early diagnosis of SM...

    Authors: Mary Curry, Rosángel Cruz, Lisa Belter, Mary Schroth, Megan Lenz and Jill Jarecki

    Citation: BMC Pediatrics 2021 21:236

    Content type: Research article

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  15. Bronchopulmonary dysplasia (BPD) infants present an increased incidence of metabolic bone disease (MBD), but it is unknown which factors contribute to this. The aim of this study was to determine the risk fact...

    Authors: Wenwen Chen, Zhenhai Zhang, Shuzhen Dai and Liping Xu

    Citation: BMC Pediatrics 2021 21:235

    Content type: Research article

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  16. The increased incidence of cardiometabolic risk factors has become a public health issue, especially in childhood and adolescence. Thus, early identification is essential to avoid or reduce future complication...

    Authors: Ana Paula Sehn, Caroline Brand, Letícia Welser, Anelise Reis Gaya, Cesar Agostinis-Sobrinho, Carlos Cristi-Montero, Elza Daniel de Mello and Cézane Priscila Reuter

    Citation: BMC Pediatrics 2021 21:234

    Content type: Research article

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  17. This study aims to determine the prevalence of tobacco smoking and illicit drug use among Dutch adolescents admitted to hospital for acute alcohol intoxication treatment. Furthermore, socio-demographic predict...

    Authors: Loes de Veld, Inge M. Wolberink, Joris J. van Hoof and Nico van der Lely

    Citation: BMC Pediatrics 2021 21:233

    Content type: Research article

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  18. Studies suggest that exposure to ambient air pollution during pregnancy may be associated with increased risks of birth defects (BDs), but conclusions have been inconsistent. This study describes the ethnic di...

    Authors: Xiaoli Huang, Jichang Chen, Dingyuan Zeng, Zhong Lin, Carly Herbert, Lesley Cottrell, Liu Liu, Arlene Ash and Bo Wang

    Citation: BMC Pediatrics 2021 21:232

    Content type: Research article

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  19. The COVID-19 outbreak has resulted in governments implementing disease containment measures such as school closures, social distancing, and home quarantine.

    Authors: G. Segre, R. Campi, F. Scarpellini, A. Clavenna, M. Zanetti, M. Cartabia and M. Bonati

    Citation: BMC Pediatrics 2021 21:231

    Content type: Research article

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  20. Alemtuzumab is a T cell depleting antibody agent used as induction immunosuppressant therapy in solid organ transplant recipients. In addition, it is being increasingly used to treat severe or glucocorticoid-r...

    Authors: Nori J. L. Smeets, Ruud J. R. Eijk, Saskia N. de Wildt and Charlotte M. H. H. T. Bootsma-Robroeks

    Citation: BMC Pediatrics 2021 21:229

    Content type: Case report

    Published on:

  21. Children’s voices are seldom heard in process evaluations concerning health promotion programmes. A Healthy School Start Plus (HSSP) is a parental support programme, conducted in Sweden, with the aim of promot...

    Authors: Mahnoush Etminan Malek, Gisela Nyberg, Liselotte Schäfer Elinder, Emma Patterson and Åsa Norman

    Citation: BMC Pediatrics 2021 21:228

    Content type: Research article

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  22. Diarrhea among children under five is one of the significant public health concerns in developing countries, such as Ethiopia that is mainly attributed to inadequate water, sanitation and hygiene (WASH) servic...

    Authors: Weldehawariyat Getahun and Metadel Adane

    Citation: BMC Pediatrics 2021 21:227

    Content type: Research article

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  23. Immunization is essential to prevent between 2 and 3 million deaths globally each year and it is widely accepted that it is one of the most cost-effective health interventions. Despite all its advantages, immu...

    Authors: Admassu Ketsela, Seifu Hagos Gebreyesus and Wakgari Deressa

    Citation: BMC Pediatrics 2021 21:226

    Content type: Research article

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  24. Physical growth during childhood and adolescence is influenced by both genetic and environmental factors. Heritability, the proportion of phenotypic variance explained by genetic factors, has been demonstrated...

    Authors: Avivit Brener, Yarden Waksman, Talya Rosenfeld, Sigal Levy, Itai Peleg, Adi Raviv, Hagar Interator and Yael Lebenthal

    Citation: BMC Pediatrics 2021 21:225

    Content type: Research article

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  25. Neonatal encephalopathy due to acute perinatal asphyxia is a major cause of perinatal brain damage. Moderate to severe neonatal encephalopathy is associated with high mortality and morbidity rates. However, th...

    Authors: Yoshinori Aoki, Tatsuo Kono, Mikako Enokizono and Kaoru Okazaki

    Citation: BMC Pediatrics 2021 21:224

    Content type: Research article

    Published on:

  26. There is a lack of a comprehensive evaluation for pediatric clinical practice guidelines (CPGs) published in recent years. Here, we assessed the quality of pediatric CPGs, considering factors that might affect...

    Authors: Yali Liu, Yuan Zhang, Shu Wang, Ling Liu, Gang Che, Jiahui Niu and Yuan Ma

    Citation: BMC Pediatrics 2021 21:223

    Content type: Research article

    Published on:

  27. Pediatric sepsis remains a significant cause of morbidity and mortality worldwide. This study aimed to identify the incidence of sepsis and septic shock among patients admitted to the pediatric intensive care ...

    Authors: Mohamed O. Humoodi, Mona A. Aldabbagh, Maher M. Salem, Yousef M. Al Talhi, Sara M. Osman, Mohammed Bakhsh, Abdullah M. Alzahrani and Maha Azzam

    Citation: BMC Pediatrics 2021 21:222

    Content type: Research article

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  28. Children with acute peripheral facial nerve palsy cannot yet be recommended corticosteroid treatment based on evidence. Adults with idiopathic facial nerve palsy are treated with corticosteroids, according to ...

    Authors: Sofia Karlsson, Sigurdur Arnason, Nermin Hadziosmanovic, Åsa Laestadius, Malou Hultcrantz, Elin Marsk and Barbro H. Skogman

    Citation: BMC Pediatrics 2021 21:220

    Content type: Study protocol

    Published on:

  29. Centralisation of paediatric intensive care units (PICUs) has the increased the need for specialist paediatric critical care transport teams (PCCT) to transport critically ill children to PICU. We investigated...

    Authors: Sarah E. Seaton, Elizabeth S. Draper, Christina Pagel, Fatemah Rajah, Jo Wray and Padmanabhan Ramnarayan

    Citation: BMC Pediatrics 2021 21:217

    Content type: Research article

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  30. Caregivers’ knowledge, practice and adherence in medication administration who care for children with chronic illness requiring long-term pharmacological treatments are factors associating with children medica...

    Authors: Chii-chii Chew, Huan-keat Chan, Chee-tao Chang, Amar-singh HSS and Mohamed azmi Hassali

    Citation: BMC Pediatrics 2021 21:216

    Content type: Research article

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  31. Adiposity status in adolescence is associated with various health outcomes in adulthood. Waist circumference [WC] and waist-to-height ratio [WHtR] are measures of abdominal obesity and have shown to be valid p...

    Authors: Felicia J. Setiono, Laura A. Guerra, Cindy Leung and Tashara M. Leak

    Citation: BMC Pediatrics 2021 21:215

    Content type: Research article

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  32. Children’s healthy development is important. While governmental public assistance benefits financially troubled families, it cannot compensate for a lack of social support. Single-parenthood is a health risk f...

    Authors: Daisuke Nishioka, Junko Saito, Keiko Ueno and Naoki Kondo

    Citation: BMC Pediatrics 2021 21:214

    Content type: Research article

    Published on:

  33. Previous studies have suggested that choline and betaine are associated with improved anthropometric measures including, BMI and waist circumference however, results are largely inconsistent and limited studie...

    Authors: Alireza Jafari, Yahya Jalilpiran, Katherine Suitor, Nick Bellissimo and Leila Azadbakht

    Citation: BMC Pediatrics 2021 21:213

    Content type: Research article

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  34. As preterm infants’ neurodevelopment is shaped by NICU-related factors during their hospitalization, it is essential to evaluate which interventions are more beneficial for their neurodevelopment at this speci...

    Authors: Marilyn Aita, Gwenaëlle De Clifford Faugère, Andréane Lavallée, Nancy Feeley, Robyn Stremler, Émilie Rioux and Marie-Hélène Proulx

    Citation: BMC Pediatrics 2021 21:210

    Content type: Research article

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  35. Centronuclear myopathy (CNM), a subtype of congenital myopathy (CM), is a group of clinical and genetically heterogeneous muscle disorders. Since the discovery of the SPEG gene and disease-causing variants, on...

    Authors: Gang Zhang, Min Xu, Tingting Huang, Wenxin Lin, Jinglin Chen, Wangyang Chen and Xingzhi Chang

    Citation: BMC Pediatrics 2021 21:209

    Content type: Case report

    Published on:

  36. Working memory performance is associated with better academic achievements in children and adolescents, and it is positively related to CRF. However, what level of cardiorespiratory fitness (CRF) discriminates...

    Authors: Vinícius Muller Reis Weber, Daniel Zanardini Fernandes, Leonardo Alex Volpato, Maria Raquel de Oliveira Bueno, Marcelo Romanzini, Jose Castro-Piñero and Enio Ricardo Vaz Ronque

    Citation: BMC Pediatrics 2021 21:208

    Content type: Research article

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  37. To examine the association of handgrip strength (HGS) and bone mineral density (BMD) of Brazilian children and adolescents.

    Authors: Bruna Thamyres Ciccotti Saraiva, Ricardo Ribeiro Agostinete, Ismael Forte Freitas Júnior, Daniel Eduardo Rodrigues de Sousa, Luis Alberto Gobbo, William Rodrigues Tebar and Diego Giulliano Destro Christofaro

    Citation: BMC Pediatrics 2021 21:207

    Content type: Research article

    Published on:

  38. Inconsistent findings have been reported for associations between protein intake and age at menarche. We aimed to investigate the association between intake of protein and protein-containing food groups during...

    Authors: Nazanin Moslehi, Golaleh Asghari, Parvin Mirmiran and Fereidoun Azizi

    Citation: BMC Pediatrics 2021 21:206

    Content type: Research article

    Published on:

  39. Left ventricular noncompaction cardiomyopathy (LVNC) is characterized by prominent ventricular trabeculations on cardiovascular imaging. Acquired reversible LVNC has not been reported in pediatrics without a g...

    Authors: Riko Kato, Hiromichi Taneichi, Shinya Takarada, Mako Okabe, Nariaki Miyao, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Yuichi Adachi, Naoki Yoshimura, Kazuyoshi Saito, Fukiko Ichida and Keiichi Hirono

    Citation: BMC Pediatrics 2021 21:205

    Content type: Case report

    Published on:

  40. Presently, 1 in 4 Lebanese adolescents is involved in bullying, with 12% being perpetrators. In Lebanon, around 90% of bullying incidents occur in schools. Given the lack of studies tackling bullying perpetrat...

    Authors: Emmanuelle Awad, Chadia Haddad, Hala Sacre, Rabih Hallit, Michel Soufia, Pascale Salameh, Sahar Obeid and Souheil Hallit

    Citation: BMC Pediatrics 2021 21:204

    Content type: Research article

    Published on:

  41. The study aims to use the cross-lagged model and utilize data from the Born in Shenyang Cohort Study to characterize the bidirectional associations of the term-born infants’ neurodevelopment in five domains an...

    Authors: Xiaotong Wei, Jiajin Hu, Liu Yang, Ming Gao, Lin Li, Ning Ding, Yanan Ma and Deliang Wen

    Citation: BMC Pediatrics 2021 21:203

    Content type: Research article

    Published on:

  42. Respiratory Syncytial Virus (RSV) is the commonest cause of acute lower respiratory infections (ALRI) in infants. However, the burden of RSV is unknown in Ethiopia. We aimed to determine the prevalence, season...

    Authors: Abate Yeshidinber Weldetsadik and Frank Riedel

    Citation: BMC Pediatrics 2021 21:201

    Content type: Research article

    Published on:

  43. Information on the foot structures of Central Anatolian children is limited. Foot structures of children aged 6–10 years were shown to be different according to sex and increasing age.

    Authors: Serap Alsancak, Senem Guner, Enver Güven, Ali Koray Özgün, Yunis Akkaş and Neslihan Alkıs

    Citation: BMC Pediatrics 2021 21:200

    Content type: Research article

    Published on:

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